Accept Everest, Langtang and Annapurna there are dozens of most popular trekking trails in Nepal. The Dolpo, Manaslu, Mustang area if the naturally personification of high passes, covered by flora and fauna and the more significantly massive picturesque Himalayan ranges which are covered by Tibetan traditional cultural heritage. Dolpo arealies between Dhaulagiri Himalayan range and Tibet from south and north known as regarded as blend of natural and cultural phenomena.
In 1991 the Dolpo region was open for trekkers and lies north side of Himalayas which is rain shadow region of Nepal which is pretty similar like Upper Mustang. The restricted area of Nepal you must be in two or more to enter the Mustang to Lomangthang. You must need 3 weeks or over time to finish Dolpo passing elevation of 5,115 meters. Located on eastern part on the border of India Kanchenjunga Trek offers massive landscapes including low land to High Himalayan range with Mt. Everest too. Kanchenjunga is second highest mountain in Nepal and third highest peak in the world. The region is covered bt Rai and LImbu people. Close to the Kanchenjunga Makalu Base Camp Trek is equally popular however tea house and lodges facilities are not available most of the nights.
To explore most spectacular ranges the Manaslu Trek being new and popular would be best choice too. Likewise Tsum valley can be combined with Manaslu Trek. Tea houses facilities are available in Manaslu And Tsum valley region.